Follow Shirley Highway (I-395) East through the 3rd Street Tunnel (I-395 North) to the Massachusetts Avenue exit. (You will actually be on New Jersey Avenue not Massachusetts Avenue.) Take New Jersey Avenue to Florida Avenue and turn left. Take Florida Avenue to Georgia Avenue (approximately three blocks) and turn right.
Take Georgia Avenue to Howard Place (approximately four blocks) and turn right. You are now on the Campus of Howard University.
Take I-66 East across the Theodore Roosevelt Memorial Bridge to Constitution Avenue. Take Constitution Avenue (23rd Street is at the end of the bridge) to 7th Street and turn left. (At Florida Avenue, 7th Street becomes Georgia Avenue.). Take Georgia Avenue to Howard Place (approximately four blocks) and turn right. You are now on the campus of Howard University.